Mechanism of action of Probiotics

Recent studies are giving new insight into the mechanisms by which the Microbiota regulates the colonization and destruction of pathogens. Particularly revealing the capacity of commensals to control pathogen development by managing the metabolic pathways that control the opposition for limited nutrients in the digestive tract. Moreover, inflammatory responses have profound effects on the development of pathogens and certain commensal species.However, the relative contributions of each metabolic pathway and the commensal species involved remain poorly understood. Furthermore, little is known about how the inflammatory responses affect interactions between pathogens and commensals. There is also a clear role for host immunity in controlling Microbiota populations. However, recent studies have challenged a critical role of innate recognition receptors in determining the composition of the gut microbiota.

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